brexpiprazole (Rexulti)

Meet with a licensed provider online to explore if an antipsychotic medication like brexpiprazole (Rexulti) may be right for you.

Treatment for:
schizophrenia, psychotic disorders, treatment-resistant depression

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What is an antipsychotic?

Antipsychotics are a class of medication that is primarily used to treat symptoms of psychosis, like hearing and seeing things that other people do not, feeling paranoid, or having delusions.

How does an antipsychotic work?

Antipsychotics work by blocking dopamine in the brain, which helps reduce the frequency and severity of psychotic symptoms.

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How prescribing works

  • 1

    Find a provider who meets your needs

    Browse our providers online or call our scheduling team for matching assistance — find a provider who accepts your insurance and meets your needs, whether that’s a clinical specialty or a shared life experience. Choose a date and time that works for you and how you’d prefer to pay (using insurance or self-pay).

  • 2

    Meet 1:1 to begin treatment

    Meet online with your provider to begin treatment. At your first session, share any symptoms or struggles you’re experiencing along with your goals. Together, you and your provider will discuss if medication may be a good next step. Your provider may write you a prescription to be filled at your local pharmacy.

  • 3

    Attend sessions and start feeling better

    Once your treatment plan is created, your provider will regularly check in and encourage feedback to ensure any medication you may be prescribed is effective for you.

FAQs

What is brexpiprazole (Rexulti) used for?

Brexpiprazole (Rexulti) is used along with other medications to treat major depressive disorder (MDD) or depression. It is also used to treat schizophrenia and agitation due to dementia in people with Alzheimer's disease.

Does brexpiprazole (Rexulti) cause weight gain or loss?

Yes, taking brexpiprazole may cause weight gain—in studies of the medication, this was a common side effect. Brexpiprazole may also cause reduced appetite, nausea, vomiting, or diarrhea, which can cause some weight loss if they are serious. If you're concerned about weight gain or loss with brexpiprazole treatment, talk with your provider. They can give you more information about the likelihood of weight changes with the medication.

How long does it take for brexpiprazole (Rexulti) to start working?

Although brexpiprazole starts working soon after you take a dose, it may take a few weeks of treatment before you notice an improvement in your condition. How long it takes brexpiprazole to work also depends on your response to treatment, the severity of your condition, your dosage, and other individual factors. Your provider will monitor you during treatment and may adjust your dose if needed to manage your condition.

Is brexpiprazole (Rexulti) a controlled substance?

No, brexpiprazole is not a controlled substance. It is not habit-forming and is not known to cause addiction. If you have other questions about how brexpiprazole works, talk with your provider or pharmacist to learn more.

Does brexpiprazole (Rexulti) help with anxiety?

Brexpiprazole is not approved for anxiety. It is used along with other medications to treat major depressive disorder, as well as schizophrenia and agitation from dementia in people with Alzheimer's disease. However, some people with depression may also have anxiety. Some studies have shown people with depression and anxiety who took brexpiprazole saw improvements in both conditions. However, in other cases, brexpiprazole treatment may cause an increase in anxiety. If you have questions about the effectiveness of brexpiprazole for anxiety, talk with your provider.

How long does brexpiprazole (Rexulti) withdrawal last?

Brexpiprazole isn't known to cause withdrawal symptoms. However, do not suddenly stop taking the medication without talking to your provider. Suddenly stopping the medication could lead to a worsening of your condition. If you'd like to stop brexpiprazole, talk with your provider about your options to do so safely.

Should I take brexpiprazole (Rexulti) in the morning or at night?

The time of day you take brexpiprazole depends on how the medication affects you and what dosing schedule works for you. Brexpiprazole may cause tiredness, sleepiness, and dizziness, so if you experience these side effects, you may want to take brexpiprazole in the evening. It's important to take the medication around the same time every day—this will help the medication keep working consistently to treat your condition. Follow your provider's directions on the time of day to take brexpiprazole.

Can I get a prescription online?

You can meet online with a licensed provider at Thriveworks — if it’s clinically appropriate, they may prescribe you medication for the treatment of a diagnosed mental health condition. Your Thriveworks provider will send your prescription to a local pharmacy to be filled.

Can I use my health insurance for online prescriptions and refills?

Thriveworks accepts most major insurance plans for our online psychiatry and therapy services. Your insurance may also cover the cost of any medication prescribed to you by your Thriveworks provider, which can be filled at a local pharmacy. Check with your insurance provider to confirm your medical and prescription coverage information.

How do I get a prescription at Thriveworks?

Schedule an online appointment with a licensed psychiatric provider at Thriveworks. After meeting with you and discussing your symptoms and treatment plan, your provider may recommend a prescription medication and/or additional services to help you reach your goals.

This information has been reviewed for accuracy and approved by our licensed psychiatric team. Published December 3, 2024

We offer psychiatry in these select states

Our psychiatry services are done completely online, so you can schedule with any psychiatric provider in your state.

Dr. Scott Gordon

Accepting medication as part of your mental health care plan is an individual and often deeply personal decision. At Thriveworks, we’re here to help you understand your care options and support you on the path toward wellness. We prioritize treating the whole patient, whether through medication, therapy, or a combination of both — guided by clinical best practices and rigorously developed treatment strategies to help clients safely and efficiently resolve their symptoms.

Dr. Scott Gordon Chief Medical Officer

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